Ke Yao Selected Research

Crystallins (Crystallin)

1/2022	Congenital cataract-causing mutation βB1-L116P is prone to amyloid fibrils aggregation and protease degradation with low structural stability.
1/2022	Cataract-Causing S93R Mutant Destabilized Structural Conformation of βB1 Crystallin Linking With Aggregates Formation and Cellular Viability.
5/2021	Cataract-causing allele in CRYAA (Y118D) proceeds through endoplasmic reticulum stress in mouse model.
1/2021	Cataract-causing mutations L45P and Y46D promote γC-crystallin aggregation by disturbing hydrogen bonds network in the second Greek key motif.
1/2021	A new heterozygous mutation in the stop codon of CRYAB (p.X176Y) is liable for congenital posterior pole cataract in a Chinese family.
1/2021	Identification and characterization of six β-crystallin gene mutations associated with congenital cataract in Chinese families.
1/2021	Cataract-causing mutations L45P and Y46D impair the thermal stability of γC-crystallin.
11/2020	Advances in pharmacotherapy of cataracts.
1/2020	The cataract-related S39C variant increases γS-crystallin sensitivity to environmental stress by destroying the intermolecular disulfide cross-links.
1/2019	Dissimilarity in the Contributions of the N-Terminal Domain Hydrophobic Core to the Structural Stability of Lens β/γ-Crystallins.

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Ke Yao Research Topics

Disease

109	Cataract (Cataracts) 02/2023 - 02/2002
35	Neoplasms (Cancer) 09/2022 - 10/2003
15	Carcinogenesis 11/2021 - 10/2003
14	Inflammation (Inflammations) 09/2022 - 03/2011
12	Glaucoma 12/2021 - 12/2002
10	Colonic Neoplasms (Colon Cancer) 01/2021 - 04/2010
9	Macular Degeneration (Age-Related Maculopathy) 09/2021 - 01/2011
9	Wounds and Injuries (Trauma) 01/2021 - 07/2014
8	Blindness (Hysterical Blindness) 05/2022 - 05/2013
8	Myopia 01/2016 - 01/2002
7	Endophthalmitis (Ophthalmia) 02/2023 - 12/2003
7	Dry Eye Syndromes (Dry Eye Syndrome) 01/2022 - 03/2015
7	Ocular Hypertension (Glaucoma, Suspect) 12/2021 - 08/2011
7	Infections 01/2021 - 10/2013
7	Lung Neoplasms (Lung Cancer) 01/2021 - 10/2003
6	Rupture 05/2021 - 04/2015
6	Skin Neoplasms (Skin Cancer) 01/2020 - 12/2012
6	Open-Angle Glaucoma (Glaucoma, Open Angle) 02/2014 - 12/2002
5	Hypoxia (Hypoxemia) 06/2020 - 10/2009
5	Macular Edema 01/2020 - 09/2004
5	Astigmatism 11/2017 - 01/2010
4	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022 - 10/2009
4	Cicatrix (Scar) 01/2022 - 07/2012
4	Pterygium 12/2021 - 01/2008
4	Capsule Opacification 01/2021 - 01/2014
4	Neoplasm Metastasis (Metastasis) 01/2018 - 01/2017
4	Pseudophakia 01/2012 - 05/2006
3	Vascular Diseases (Vascular Disease) 09/2022 - 01/2021
3	Corneal Injuries 05/2022 - 01/2010
3	Diabetes Mellitus 01/2022 - 04/2015
3	Bacterial Infections (Bacterial Infection) 01/2021 - 01/2019
3	Body Weight (Weight, Body) 01/2021 - 01/2014
3	Keratitis 11/2020 - 01/2016
3	Retinal Detachment (Retinal Detachments) 02/2020 - 09/2002
3	Corneal Neovascularization 01/2020 - 05/2002
3	Colorectal Neoplasms (Colorectal Cancer) 06/2019 - 04/2010
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018 - 10/2014
3	Hypertension (High Blood Pressure) 01/2018 - 04/2015
3	Lymphatic Metastasis 01/2017 - 10/2003
3	Hemorrhage 01/2014 - 09/2002
3	Hyperopia (Hypermetropia) 01/2012 - 01/2011
3	Contusions 08/2009 - 03/2006
2	zonular Cataract 10/2022 - 10/2021

Drug/Important Bio-Agent (IBA)

30	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2003
25	Crystallins (Crystallin)IBA 01/2022 - 07/2003
19	Retinaldehyde (Retinal)IBA 09/2022 - 09/2004
16	Pharmaceutical PreparationsIBA 09/2022 - 05/2013
7	Capsules (Microcapsules)IBA 02/2022 - 04/2015
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2021 - 01/2012
5	Anti-Bacterial Agents (Antibiotics)IBA 02/2023 - 01/2017
5	Therapeutic UsesIBA 05/2022 - 01/2007
5	CollagenIBA 01/2022 - 01/2012
5	Phosphotransferases (Kinase)IBA 11/2021 - 12/2015
5	Ophthalmic Solutions (Eye Drops)IBA 11/2020 - 09/2010
5	Fluorescein (Funduscein)FDA LinkGeneric 04/2020 - 09/2008
5	Epidermal Growth Factor (EGF)IBA 01/2020 - 01/2011
4	AlkaliesIBA 05/2022 - 05/2002
4	bromfenac FDA Link 03/2022 - 01/2013
4	Oxygen (Dioxygen)IBA 02/2022 - 07/2012
4	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 11/2008
4	LanosterolIBA 10/2021 - 12/2018
4	CytokinesIBA 01/2021 - 03/2011
4	Protein Kinases (Protein Kinase)IBA 01/2020 - 01/2017
4	SolutionsIBA 01/2015 - 06/2003
3	Gatifloxacin (Zymar)FDA Link 02/2023 - 11/2009
3	Codon (Codons)IBA 10/2022 - 01/2021
3	Liposomes (Liposome)IBA 05/2022 - 06/2003
3	ChitosanIBA 01/2022 - 07/2014
3	Messenger RNA (mRNA)IBA 01/2022 - 07/2012
3	SilverIBA 01/2021 - 01/2020
3	Biological ProductsIBA 01/2021 - 04/2010
3	Caspase 3 (Caspase-3)IBA 10/2020 - 07/2003
3	GoldIBA 01/2020 - 09/2017
3	connexin 50IBA 01/2016 - 01/2013
3	Nonsense Codon (Nonsense Mutation)IBA 01/2014 - 07/2008
3	Fibrillin-1IBA 08/2009 - 07/2007
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 09/2022 - 01/2017
2	Particulate MatterIBA 09/2022 - 12/2021
2	Biomarkers (Surrogate Marker)IBA 02/2022 - 06/2015
2	Streptozocin (Streptozotocin)FDA Link 01/2022 - 11/2020
2	EnzymesIBA 01/2022 - 01/2021
2	MicellesIBA 01/2022 - 01/2020

Therapy/Procedure

32	Phacoemulsification 03/2022 - 12/2003
27	Therapeutics 05/2022 - 01/2011
26	Lasers (Laser) 03/2022 - 09/2002
16	Intraocular Lenses (Intraocular Lens) 02/2023 - 01/2002
7	Laser In Situ Keratomileusis (LASIK) 01/2016 - 03/2002
6	Vitrectomy 11/2016 - 09/2004
6	Intraocular Lens Implantation 03/2015 - 01/2004
5	Lenses 10/2021 - 05/2002
5	Cautery 01/2021 - 05/2002
5	Sutures (Suture) 01/2014 - 01/2008
4	Chemoprevention 10/2021 - 09/2014
4	Capsulorhexis 01/2021 - 01/2016
4	Drug Therapy (Chemotherapy) 11/2020 - 07/2014
4	Corneal Transplantation (Keratoplasty) 01/2012 - 01/2010
3	Photochemotherapy (Photodynamic Therapy) 11/2020 - 06/2007
3	Refractive Surgical Procedures 01/2020 - 01/2012
3	Telescopes 01/2020 - 03/2005
3	Photothermal Therapy 01/2020 - 09/2017